Dualitas (pronunciation: doo-AWL-ih-tahs) was founded in 2023 by a team of world-class biotherapeutic engineers and drug developers to fundamentally transform how differentiated bispecific antibody (BsAb) therapies are discovered.
Unlike traditional typically narrow approaches to bispecific discovery, our proprietary DualScreen™ Bispecific Discovery Engine operates at combinatorial scale to enable discovery of unexplored co-target combinations and novel cell-surface proximity biology, delivering bispecific candidates with highly differentiated activity.
Our portfolio, built from DualScreen, includes lead programs DTX-102 in autoimmune disease and DTX-103 in allergic disease. Each candidate has demonstrated differentiated preclinical profiles when benchmarked to available therapies.
DualScreen™ Bispecific Discovery Engine
Existing BsAb discovery approaches narrowly focus on pre-determined target pairs of known biology. In contrast, DualScreen functionally screens cell surfaceomes – the entire cell surface – across a vast range of targets and epitopes to identify BsAb combinations that are truly synergistic rather than simply additive. Up to 100,000+ unique bispecific combinations can be arrayed and screened in high throughput functional assays to identify BsAbs and co-targets with synergistic activities unachievable by conventional therapeutics. DualScreen discovers powerful cell surface proximity mechanisms and rapidly delivers BsAbs with differentiated pharmacology.
Immune Proximity Engagers
DualScreen has discovered an expanding collection of novel cell-surface proximity engagers — reusable antibody arms that can be plugged into a wide range of BsAbs to elicit repeatable proximity mechanisms. Dualitas’ engagers can be paired with antibody arms to diverse disease-relevant immune targets to impart differentiated pharmacology that monospecific agents cannot achieve. Dualitas’ two lead programs utilize Engager E1 to bring substantial differentiation to validated therapeutic pathways.
Dualitas’ proprietary “E1” Proximity Engager can "Plug and Play" across receptors to enhance pharmacologic activity
- As BsAb:
- Greater potency
- Enhanced efficacy (Emax) and immune modulation beyond competitive inhibition
- Efficacy where validated therapies are limited
- E1 BsAb engagement has confirmed enhanced activity with numerous different receptors
- Inert as monovalent monospecific
Dualitas Bispecific Pipeline
Dualitas is advancing a pipeline of highly differentiated novel bispecific antibodies that bring powerful cell-surface proximity engager mechanisms to therapeutically validated pathways to treat autoimmune, allergic, and other immune and inflammatory (I&I) diseases.
Our pipeline candidates were discovered from DualScreen and have demonstrated differentiated pharmacology in preclinical studies, including:
- Significant increases in potency
- Enhanced efficacy (Emax) and immune modulation beyond conventional inhibitors
- Rapid onset of action independent of ligand competition
- Conversion of inert antibodies into highly active agents that are directed to specific cell types
Pioneering the Future of BsAb Therapies for Patients & Partners
Dualitas offers a variety of strategic collaboration opportunities to extend the impact of its DualScreen discovery engine, ranging from existing pipeline programs to identifying de novo BsAbs, to establishing programs in disease areas beyond I&I.
Our Team
Leadership
Rich Murray, Ph.D.
Interim Chief Executive Officer and Board Member
Greg Lazar, Ph.D.
Co-Founder and Chief Scientific Officer
Forbes Huang
Co-Founder, Chief Operating Officer & Chief Business Officer
Rich Murray, Ph.D.
Interim Chief Executive Officer and Board Member
Dr. Rich Murray has over 30 years of industry experience in the fields of immunology and cancer, centered on protein and antibody therapeutics research, from early-stage innovations through product approvals. He is currently senior advisor to Qiming Ventures USA, and was most recently CEO of Jounce Therapeutics, an immuno-oncology focused company. He led the company through private and public financings and numerous substantial business deals. He was SVP of Biologics and Vaccines at Merck establishing their Biologics capabilities and was instrumental in the research and development of Keytruda. Previously he was CSO at Protein Design Labs overseeing antibody technologies, pipeline, and manufacturing prior to acquisition by Abbott, now AbbVie. He was a founder and VP of Research at Eos Biotech leading to its acquisition by Protein Design Labs. Rich has served on both public and private company Boards. He received his PhD in immunology and microbiology at the University of North Carolina where he was a Lineberger Cancer Research fellow and did his post-doctoral research at DNAX Research Institute.
Greg Lazar, Ph.D.
Co-Founder and Chief Scientific Officer
Dr. Lazar is Co-Founder and Chief Scientific Officer at Dualitas Therapeutics. Prior to Dualitas he led research groups at Genentech, Eli Lilly, and Xencor. Together with colleagues, Dr. Lazar has developed multiple technologies for optimizing antibodies and therapeutic proteins, and contributed to numerous clinical stage molecules including several approved drugs. He is an inventor of over 30 patents and has authored over 40 scientific publications in the fields of protein design, biotherapeutic engineering, and drug discovery. Dr. Lazar holds a BS in Molecular & Cell Biology with Chemistry Honors from Penn State and a PhD in Molecular & Cell Biology from UC Berkeley, and was a Jane Coffin Childs Fellow at the University of Cambridge.
Forbes Huang
Co-Founder, Chief Operating Officer & Chief Business Officer
Forbes Huang is Co-Founder, Chief Operating Officer and Chief Business Officer of Dualitas Therapeutics overseeing operations, business development, portfolio management, investor relations, human resources, and finance for the Company. He was previously CEO for a Novo Holdings startup (acquired by Insmed); Senior Vice President of Corporate Development at Gyroscope Therapeutics (acquired by Novartis), and Vice President of Business Development & Operations at IVERIC bio (acquired by Astellas). He began his career in investment banking at Morgan Stanley advising on biotech IPOs, M&A, and financing, and private equity investing at H.I.G. Capital.
Forbes received his MBA from The Wharton School of the University of Pennsylvania with highest distinction as a Palmer Scholar. He is an appointed Senior Fellow with The Wharton School and served as Executive-in-Residence at the Penn Center for Innovation. He earned dual bachelor’s degrees in Finance and Economics from New York University’s Stern School of Business graduating summa cum laude.
Board of Directors
Neil Weir, Ph.D.
Executive Chairman of the Board
Thomas Hudson, M.D.
Venture Partner, Versant Ventures
Alicia Levey, Ph.D.
Venture Partner, Versant Ventures
Mark McDade
Partner, Qiming Venture Partners USA
Rich Murray, Ph.D.
Interim CEO, Dualitas Therapeutics
Mike Ross, Ph.D.
Senior Partner, SV Health Investors
Nikola Trbovic, Ph.D.
Managing Partner, SV Health Investors
Investors
Working at Dualitas
Dualitas is a science-first company built on homegrown innovation. Our focused, fast-moving team works to unlock new biology and reimagine what bispecific medicines can achieve. With discipline, curiosity, and momentum, we are driven to transform patient care through next-generation bispecifics — and we welcome colleagues eager to bring this vision to fruition.