Dualitas (pronunciation: doo-AWL-ih-tahs) was founded in 2023 by a team of world-class biotherapeutic engineers and drug developers to fundamentally transform how differentiated bispecific antibody (BsAb) therapies are discovered.

Unlike traditional typically narrow approaches to bispecific discovery, our proprietary DualScreen™ Bispecific Discovery Engine operates at combinatorial scale to enable discovery of unexplored co-target combinations and novel cell-surface proximity biology, delivering bispecific candidates with highly differentiated activity.

Our portfolio, built from DualScreen, includes lead programs DTX-102 in autoimmune disease and DTX-103 in allergic disease. Each candidate has demonstrated differentiated preclinical profiles when benchmarked to available therapies. 

DualScreen™ Bispecific Discovery Engine 

Existing BsAb discovery approaches narrowly focus on pre-determined target pairs of known biology. In contrast, DualScreen functionally screens cell surfaceomes – the entire cell surface – across a vast range of targets and epitopes to identify BsAb combinations that are truly synergistic rather than simply additive. Up to 100,000+ unique bispecific combinations can be arrayed and screened in high throughput functional assays to identify BsAbs and co-targets with synergistic activities unachievable by conventional therapeutics. DualScreen discovers powerful cell surface proximity mechanisms and rapidly delivers BsAbs with differentiated pharmacology.

Immune Proximity Engagers

DualScreen has discovered an expanding collection of novel cell-surface proximity engagers — reusable antibody arms that can be plugged into a wide range of BsAbs to elicit repeatable proximity mechanisms. Dualitas’ engagers can be paired with antibody arms to diverse disease-relevant immune targets to impart differentiated pharmacology that monospecific agents cannot achieve. Dualitas’ two lead programs utilize Engager E1 to bring substantial differentiation to validated therapeutic pathways.

Dualitas’ proprietary “E1” Proximity Engager can "Plug and Play" across receptors to enhance pharmacologic activity

  • As BsAb: 
  1. Greater potency
  2. Enhanced efficacy (Emax) and immune modulation beyond competitive inhibition
  3. Efficacy where validated therapies are limited 
  • E1 BsAb engagement has confirmed enhanced activity with numerous different receptors
  • Inert as monovalent monospecific
     

Dualitas Bispecific Pipeline

Dualitas is advancing a pipeline of highly differentiated novel bispecific antibodies that bring powerful cell-surface proximity engager mechanisms to therapeutically validated pathways to treat autoimmune, allergic, and other immune and inflammatory (I&I) diseases.

dualitas_pipeline
dualitas_pipeline

Our pipeline candidates were discovered from DualScreen and have demonstrated differentiated pharmacology in preclinical studies, including:

  • Significant increases in potency
  • Enhanced efficacy (Emax) and immune modulation beyond conventional inhibitors 
  • Rapid onset of action independent of ligand competition
  • Conversion of inert antibodies into highly active agents that are directed to specific cell types

Pioneering the Future of BsAb Therapies for Patients & Partners

Dualitas offers a variety of strategic collaboration opportunities to extend the impact of its DualScreen discovery engine, ranging from existing pipeline programs to identifying de novo BsAbs, to establishing programs in disease areas beyond I&I. 

Partner with us

Our Team

Leadership

Rich Murray, Ph.D.

Interim Chief Executive Officer and Board Member

Greg Lazar, Ph.D.

Co-Founder and Chief Scientific Officer

Forbes Huang

Co-Founder, Chief Operating Officer & Chief Business Officer

Board of Directors

Neil Weir, Ph.D.

Executive Chairman of the Board

Thomas Hudson, M.D.

Venture Partner, Versant Ventures

Alicia Levey, Ph.D.

Venture Partner, Versant Ventures

Mark McDade

Partner, Qiming Venture Partners USA

Rich Murray, Ph.D.

Interim CEO, Dualitas Therapeutics

Mike Ross, Ph.D.

Senior Partner, SV Health Investors

Nikola Trbovic, Ph.D.

Managing Partner, SV Health Investors

Investors

Working at Dualitas

Dualitas is a science-first company built on homegrown innovation. Our focused, fast-moving team works to unlock new biology and reimagine what bispecific medicines can achieve. With discipline, curiosity, and momentum, we are driven to transform patient care through next-generation bispecifics — and we welcome colleagues eager to bring this vision to fruition.

Join our team