Dualitas (pronunciation: doo-AWL-ih-tahs) was founded in 2023 by a team of world-class biotherapeutic engineers and drug developers to fundamentally transform how differentiated bispecific antibody (BsAb) therapies are developed.

Our Proximity Engagers Supercharge Therapeutic Activity

Dualitas’ bispecific antibodies pair a proprietary proximity engager arm with an antibody against a therapeutic target. Unlike traditional bispecific approaches that seek incremental gains by combining two separate inhibitors, Dualitas’ engager bispecifics elicit enhanced pharmacological effects that are achievable only in a bispecific format and cannot be achieved with monospecific agents.

Synergistic Mechanism

Dualitas is applying its bispecific proximity engager across multiple validated immune pathways

immune engagers chartsimmune engagers charts

Dualitas Pipeline

Dualitas is advancing a pipeline of novel highly differentiated bispecific antibodies that bring powerful cell-surface proximity engager mechanisms to therapeutically validated pathways to treat autoimmune, allergic, and other immune and inflammatory (I&I) diseases.

dualitas_pipeline
dualitas_pipeline

Our pipeline candidates were discovered internally via our DualScreen Engine and have demonstrated differentiated pharmacology in preclinical studies, including:

  • Significant increases in potency
  • Enhanced efficacy (Emax) and immune modulation beyond conventional inhibitors 
  • Rapid onset of action independent of ligand competition
  • Conversion of inert antibodies into highly active agents that are directed to specific cell types
     

DTX-102

DTX-102, our lead development candidate, is a bispecific antibody that pairs an optimized anti-CD28 antibody arm with a highly potent immune proximity engager for the treatment of rheumatoid arthritis. In preclinical studies, DTX-102 was shown to have substantially more potent activity and more favorable dosing potential compared to a commercially approved agent.

IND-enabling studies for DTX-102 are underway.

dtx102

 

DTX-101

DTX-101 pairs an anti-IL-2Rβ antibody arm with a proximity engager arm, with initial indications in dermatologic and gastrointestinal autoimmune disease.

dtx103

 

DTX-103

DTX-103 is a bispecific antibody pairing an anti-FcεR1 arm with a proximity engager arm for the treatment of allergic diseases. The DTX-103 mechanism is independent of IgE concentrations, bypassing limitations of current therapies, that include slow action onset and patient restrictions. DTX-103 is being developed to deliver rapid and superior pharmacology for an expanded treatable population.

dtx103

 

Early Pipeline

We continue to discover new bispecific target combinations that leverage our proximity engager technology to deliver synergistic and superior pharmacology.

dtx101

DualScreen™ Bispecific Discovery Engine 

Existing BsAb discovery approaches narrowly focus on pre-determined target pairs of known biology. In contrast, DualScreen functionally screens cell surfaceomes – the entire cell surface – across a vast range of targets and epitopes to identify BsAb combinations that are truly synergistic rather than simply additive. Up to 100,000+ unique bispecific combinations can be arrayed and screened in high throughput functional assays to identify BsAbs and co-targets with synergistic activities unachievable by conventional therapeutics. DualScreen discovers powerful cell surface proximity mechanisms and rapidly delivers BsAbs with differentiated pharmacology. 

Dualitas’ internal pipeline and Proximity Engagers were discovered internally via DualScreen.
 

Pioneering the Future of BsAb Therapies for Patients & Partners

Dualitas offers a variety of strategic collaboration opportunities to extend the impact of its DualScreen discovery engine, ranging from existing pipeline programs to identifying de novo BsAbs, to establishing programs in disease areas beyond I&I. 

Partner with us

Our Team

Leadership

Karim Dabbagh

Karim Dabbagh, Ph.D.

Chief Executive Officer,
Board Member

Greg Lazar, Ph.D.

Co-Founder and Chief Scientific Officer

Forbes Huang

Co-Founder, Chief Operating Officer & Chief Business Officer

Board of Directors

Neil Weir, Ph.D.

Chairman of the Board

David E. Cohen, M.D., M.P.H.

NYU Langone Health

Karim Dabbagh, Ph.D.

CEO, Dualitas Therapeutics

Thomas Hudson, M.D.

Venture Partner, Versant Ventures

Alicia Levey, Ph.D.

Venture Partner, Versant Ventures

Mark McDade

Partner, Qiming Venture Partners USA

Rich Murray, Ph.D.

Board Member

Mike Ross, Ph.D.

Senior Partner, SV Health Investors

Nikola Trbovic, Ph.D.

Managing Partner, SV Health Investors

Investors

Working at Dualitas

Dualitas is a science-first company built on homegrown innovation. Our focused, fast-moving team works to unlock new biology and reimagine what bispecific medicines can achieve. With discipline, curiosity, and momentum, we are driven to transform patient care through next-generation bispecifics — and we welcome colleagues eager to bring this vision to fruition.

Join our team

 

Notice on Fraudulent Job Offers and Recruiting Activities
Dualitas Therapeutics has been made aware of fraudulent recruiting activity in which individuals falsely claim to represent our company. These scammers may offer fake job opportunities and attempt to collect personal or financial information. All legitimate communication from Dualitas comes from email addresses ending in @dualitastx.com. Our only official website is www.dualitastx.com, and our official LinkedIn page is linkedin.com/company/dualitas-therapeutics. Any other domains, pages, or variations should be considered suspicious.

Dualitas does not conduct interviews through text or messaging apps, does not ask candidates to download software, does not request payments or financial information, and does not issue job offers without in‑person interviews. Messages that do not align with these practices are fraudulent.