Dualitas (pronunciation: doo-AWL-ih-tahs) was founded in 2023 by a team of world-class biotherapeutic engineers and drug developers to fundamentally transform how differentiated bispecific antibody (BsAb) therapies are developed.
Our Proximity Engagers Supercharge Therapeutic Activity
Dualitas’ bispecific antibodies pair a proprietary proximity engager arm with an antibody against a therapeutic target. Unlike traditional bispecific approaches that seek incremental gains by combining two separate inhibitors, Dualitas’ engager bispecifics elicit enhanced pharmacological effects that are achievable only in a bispecific format and cannot be achieved with monospecific agents.
Synergistic Mechanism

Dualitas is applying its bispecific proximity engager across multiple validated immune pathways


Dualitas Pipeline
Dualitas is advancing a pipeline of novel highly differentiated bispecific antibodies that bring powerful cell-surface proximity engager mechanisms to therapeutically validated pathways to treat autoimmune, allergic, and other immune and inflammatory (I&I) diseases.


Our pipeline candidates were discovered internally via our DualScreen Engine and have demonstrated differentiated pharmacology in preclinical studies, including:
- Significant increases in potency
- Enhanced efficacy (Emax) and immune modulation beyond conventional inhibitors
- Rapid onset of action independent of ligand competition
- Conversion of inert antibodies into highly active agents that are directed to specific cell types
DTX-102
DTX-102, our lead development candidate, is a bispecific antibody that pairs an optimized anti-CD28 antibody arm with a highly potent immune proximity engager for the treatment of rheumatoid arthritis. In preclinical studies, DTX-102 was shown to have substantially more potent activity and more favorable dosing potential compared to a commercially approved agent.
IND-enabling studies for DTX-102 are underway.

DTX-101
DTX-101 pairs an anti-IL-2Rβ antibody arm with a proximity engager arm, with initial indications in dermatologic and gastrointestinal autoimmune disease.

DTX-103
DTX-103 is a bispecific antibody pairing an anti-FcεR1 arm with a proximity engager arm for the treatment of allergic diseases. The DTX-103 mechanism is independent of IgE concentrations, bypassing limitations of current therapies, that include slow action onset and patient restrictions. DTX-103 is being developed to deliver rapid and superior pharmacology for an expanded treatable population.

Early Pipeline
We continue to discover new bispecific target combinations that leverage our proximity engager technology to deliver synergistic and superior pharmacology.

DualScreen™ Bispecific Discovery Engine
Existing BsAb discovery approaches narrowly focus on pre-determined target pairs of known biology. In contrast, DualScreen functionally screens cell surfaceomes – the entire cell surface – across a vast range of targets and epitopes to identify BsAb combinations that are truly synergistic rather than simply additive. Up to 100,000+ unique bispecific combinations can be arrayed and screened in high throughput functional assays to identify BsAbs and co-targets with synergistic activities unachievable by conventional therapeutics. DualScreen discovers powerful cell surface proximity mechanisms and rapidly delivers BsAbs with differentiated pharmacology.
Dualitas’ internal pipeline and Proximity Engagers were discovered internally via DualScreen.


Pioneering the Future of BsAb Therapies for Patients & Partners
Dualitas offers a variety of strategic collaboration opportunities to extend the impact of its DualScreen discovery engine, ranging from existing pipeline programs to identifying de novo BsAbs, to establishing programs in disease areas beyond I&I.
Our Team
Leadership

Karim Dabbagh, Ph.D.
Chief Executive Officer,
Board Member

Greg Lazar, Ph.D.
Co-Founder and Chief Scientific Officer

Forbes Huang
Co-Founder, Chief Operating Officer & Chief Business Officer

Karim Dabbagh, Ph.D.
Chief Executive Officer, Board Member
Dr. Dabbagh has spent more than two decades in biotech and pharma leadership, specializing in I&I. He joins Dualitas from Silver Creek Pharmaceuticals, where he was President and CEO. Prior to that, he served as President and CEO of Second Genome, helping build the company’s R&D platform and advancing its pipeline from discovery into the clinic, while also securing collaborations with Gilead Sciences and Bayer. Earlier in his career, he led Pfizer’s immunoregulation department as well as external R&D innovation efforts in autoimmune and inflammatory diseases, and previously held leadership roles in Inflammation Discovery Research at Roche.

Greg Lazar, Ph.D.
Co-Founder and Chief Scientific Officer
Dr. Lazar is Co-Founder and Chief Scientific Officer at Dualitas Therapeutics. Prior to Dualitas he led research groups at Genentech, Eli Lilly, and Xencor. Together with colleagues, Dr. Lazar has developed multiple technologies for optimizing antibodies and therapeutic proteins, and contributed to numerous clinical stage molecules including several approved drugs. He is an inventor of over 30 patents and has authored over 40 scientific publications in the fields of protein design, biotherapeutic engineering, and drug discovery. Dr. Lazar holds a BS in Molecular & Cell Biology with Chemistry Honors from Penn State and a PhD in Molecular & Cell Biology from UC Berkeley, and was a Jane Coffin Childs Fellow at the University of Cambridge.

Forbes Huang
Co-Founder, Chief Operating Officer & Chief Business Officer
Forbes Huang is Co-Founder, Chief Operating Officer and Chief Business Officer of Dualitas Therapeutics overseeing operations, business development, portfolio management, investor relations, human resources, and finance for the Company. He was previously CEO for a Novo Holdings startup (acquired by Insmed); Senior Vice President of Corporate Development at Gyroscope Therapeutics (acquired by Novartis), and Vice President of Business Development & Operations at IVERIC bio (acquired by Astellas). He began his career in investment banking at Morgan Stanley advising on biotech IPOs, M&A, and financing, and private equity investing at H.I.G. Capital.
Forbes received his MBA from The Wharton School of the University of Pennsylvania with highest distinction as a Palmer Scholar. He is an appointed Senior Fellow with The Wharton School and served as Executive-in-Residence at the Penn Center for Innovation. He earned dual bachelor’s degrees in Finance and Economics from New York University’s Stern School of Business graduating summa cum laude.
Board of Directors
Neil Weir, Ph.D.
Chairman of the Board
David E. Cohen, M.D., M.P.H.
NYU Langone Health
Karim Dabbagh, Ph.D.
CEO, Dualitas Therapeutics
Thomas Hudson, M.D.
Venture Partner, Versant Ventures
Alicia Levey, Ph.D.
Venture Partner, Versant Ventures
Mark McDade
Partner, Qiming Venture Partners USA
Rich Murray, Ph.D.
Board Member
Mike Ross, Ph.D.
Senior Partner, SV Health Investors
Nikola Trbovic, Ph.D.
Managing Partner, SV Health Investors
Investors






Working at Dualitas
Dualitas is a science-first company built on homegrown innovation. Our focused, fast-moving team works to unlock new biology and reimagine what bispecific medicines can achieve. With discipline, curiosity, and momentum, we are driven to transform patient care through next-generation bispecifics — and we welcome colleagues eager to bring this vision to fruition.
Notice on Fraudulent Job Offers and Recruiting Activities
Dualitas Therapeutics has been made aware of fraudulent recruiting activity in which individuals falsely claim to represent our company. These scammers may offer fake job opportunities and attempt to collect personal or financial information. All legitimate communication from Dualitas comes from email addresses ending in @dualitastx.com. Our only official website is www.dualitastx.com, and our official LinkedIn page is linkedin.com/company/dualitas-therapeutics. Any other domains, pages, or variations should be considered suspicious.
Dualitas does not conduct interviews through text or messaging apps, does not ask candidates to download software, does not request payments or financial information, and does not issue job offers without in‑person interviews. Messages that do not align with these practices are fraudulent.
